The prognostic significance of p16 status in patients with vulvar cancer treated with vulvectomy and adjuvant radiation

This is a retrospective analysis from a single institution examining 39 women with vulvar squamous cell carcinoma treated with adjuvant radiation therapy noting how outcomes differed according to p16 status—measured through immunohistochemistry. We observed fewer in-field relapses and improved progression-free survival in women whose tumors were p16 positive. There was no difference in overall survival between groups. This is the largest cohort of patients treated with adjuvant radiation therapy with known p16 status.

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