Reply

We thank Drs Crino and Larghi for their comments. We do agree that endoscopic ultrasound–guided fine-needle biopsy (EUS-FNB) is preferred over EUS-guided fine-needle aspiration (EUS-FNA) for tissue acquisition, except for the following: (1) when the patient is borderline coagulopathic or when anticoagulation cannot be discontinued but a tissue diagnosis still is desired (risk of bleeding may be higher with FNB), or (2) for sampling pancreatic cyst lesions (the risk of pancreatitis may be higher with FNB).

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