Hypertrophic Herpes Simplex—Pseudocarcinoma

Individuals with human immunodeficiency virus (HIV) are commonly coinfected with herpes simplex virus type 2 (HSV-2) and human papilloma virus (HPV). Herpes simplex virus type 2 in HIV-infected individuals can present as atypical hypertrophic lesions, and HPV-induced malignant lesions can present as atypical hyperkeratotic lesions. We report a case of an atypical hypertrophic HSV-2 lesion in a well-managed HIV-infected male with a history of nonmalignant Buschke-Lowenstein tumor (giant condyloma) of HPV and squamous cell carcinoma of the scrotum. Determining the definitive diagnosis of hypertrophic HSV-2 in this patient was confounded by the macroscopic clinical presentation of the proliferative lesion and by the patient's history of squamous cell carcinoma, in the same perineal region. Knowledge of hypertrophic HSV-2 is imperative when considering the etiologic agent of anogenital lesions in HIV-infected individuals. Correspondence to: Laura R. Parker, BA, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane W, Piscataway Township, NJ 08854. E-mail: lrp87@rwjms.rutgers.edu. The authors have no funding or conflicts of interest to disclose. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2LGlsGY