Diuretics in newborns born extremely premature: the jury is still out

In their study, Blaisdell et al conclude that diuretics do not "substantially improve the respiratory status of the infant born extremely premature."1 I disagree with this interpretation. The main outcome measure of the study was "change in the respiratory status," defined on the basis of 5 very broad categories ("deceased," "endotracheal tube," "continuous positive airway pressure or nasal cannula >2 liters per minute," "nasal cannula <2 LPM," and "no support"; their Table II) that are not sensitive enough to detect the incremental improvement that may result from the use of diuretics.

https://ift.tt/2JvF6ng