Significance of Negative Post-Treatment 18-FDG PET/CT Imaging in Patients with p16/HPV-positive Oropharyngeal Cancer

Patients with HPV-associated oropharyngeal cancer have a favorable outcome after treatment. The optimal surveillance strategy and modality is not well established. A retrospective analysis of 327 patients with HPV-associated oropharyngeal cancer who received definitive (chemo)radiotherapy who had post-treatment PET/CT was performed. This study showed that patients who achieve a complete metabolic response on post-treatment PET imaging have excellent prognosis and the risk of developing a recurrence in the future is very low (8%).

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