Impact of Immunohistochemistry-Based Subtypes in Muscle-Invasive Bladder Cancer on Response to Chemoradiotherapy

Patients with muscle-invasive bladder cancer undergoing chemoradiotherapy (CRT) were analyzed to evaluate possible impact of immunohistochemistry-based subtypes on CRT response. Subtypes were determined using the model developed by Lund University; genomically unstable and squamous cell cancer-like subtypes, which have aggressive features and intrinsically poor prognoses, showed significantly more favorable CRT responses than urobasal subtype. In this series, cancer-specific mortalities (CSM) were equivalent among the subtypes, while favorable CRT response independently correlated with low CSM.

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