The novel phage-derived antimicrobial agent HY-133 is active against livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) [PublishAheadOfPrint]

Livestock-associated, methicillin-resistant Staphylococcus aureus (LA-MRSA) are increasingly migrating from livestock into human and animal health care settings. Alternative substances are wanted to overcome the drawbacks of currently available drugs applied for MRSA eradication. The recombinant bacteriophage endolysin HY-133 has been proven as an active agent against S. aureus. Here, the in vitro activity of HY-133 was studied against a large collection of genetically diverse LA-MRSA revealing its high activity against mecA, mecB and mecC LA-MRSA.

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