Moringa oleifera Leaves Extract Protects Titanium Dioxide Nanoparticles-Induced Nephrotoxicity via Nrf2/HO-1 Signaling and Amelioration of Oxidative Stress

Abstract

The efficacy of Moringa oleifera leaf extract (MO) in alleviating nephrotoxicity induced by titanium dioxide nanoparticles (TiO₂ NPs) was studied. Rats were divided into four groups. Group I received distilled water. Group II received TiO₂NPs. Group III received both TiO₂NPs suspension beside MO. Group IV received MO only. Kidney KIM-1, NF-кB TNF-α, and HSP-70 expression were significantly upregulated while both Nrf2 and HO-1were significantly downregulated in TiO₂NPs-treated rats. MO decreases expression of KIM-1, NF-кB, TNF-α, and HSP-70. In addition, MO has markedly upregulated the expression of Nrf2 and HO-1. In conclusion, MO can inhibit nephrotoxicity by suppressing oxidative stress and inflammation. These effects are suggested to be mediated by activating Nrf2/HO-1.The biochemical analysis and histopathological finding reinforced these results. These data support the antioxidant properties' nutraceutical role of MO against TiO₂NPs-induced toxicity.

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