Effect of Body Temperature on Cerebral Autoregulation in Acutely Comatose Neurocritically Ill Patients

Objectives: Impaired cerebral autoregulation following neurologic injury is a predictor of poor clinical outcome. We aimed to assess the relationship between body temperature and cerebral autoregulation in comatose patients. Design: Retrospective analysis of prospectively collected data. Setting: Neurocritical care unit of the Johns Hopkins Hospital. Patients: Eighty-five acutely comatose patients (Glasgow Coma Scale score of ≤ 8) admitted between 2013 and 2017. Interventions: None. Measurement and Main Results: Cerebral autoregulation was monitored using multimodal monitoring with near-infrared spectroscopy–derived cerebral oximetry index. Cerebral oximetry index was calculated as a Pearson correlation coefficient between low-frequency changes in regional cerebral oxygenation saturation and mean arterial pressure. Patients were initially analyzed together, then stratified by temperature pattern over the monitoring period: no change (

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