Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

The intestinal epithelium is constantly renewed through cell shedding and stem cell activation, and this renewal maintains intestinal barrier integrity. Zhai et al. show that in Drosophila, activation of the Imd-NF-κB pathway upon bacterial infection not only induces the expression of antimicrobial peptides, but also controls epithelial shedding, suggesting an evolutionarily conserved crosstalk between immunity and epithelial turnover.

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