PRESERVE: The End or the Beginning of a New Era in Prevention of Contrast-Associated Acute Kidney Injury?

Acute kidney injury (AKI) following the administration of iodinated contrast media has been widely recognized and studied since the initial reports in the 1950s.1 The decrease in glomerular filtration rate (GFR) occurs almost immediately upon exposure to contrast media and is reflected in an increase in serum creatinine (or cystatin C) level, usually within 24 to 48 hours before creatinine levels gradually return to near baseline within 5 to 7 days. Despite the predominantly transient nature of the increase in creatinine level, this AKI has been associated with a variety of short- and long-term adverse outcomes, including extended hospitalization and health care costs.

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