The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output

Bulut-Karslioglu et al. show that the transcriptionally permissive chromatin landscapes in mouse embryonic stem cells and blastocysts are acutely sensitive to variations in translational output. This positive feedback loop between permissive chromatin and translation, in turn, may set the rapid pace of growth during early embryonic development.

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