SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation

Wu and colleagues define SETD7 as a key regulator of cardiac lineage commitment. SETD7 regulates the expression of lineage-specific target genes and interacts with various co-factors during cardiomyocyte differentiation. SETD7 associates with H3K36me3 histone modification, which is required for the transcriptional activation.

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