Relationship between age and nerve dimensions in Charcot-Marie-Tooth disease. Do we know the reality?

We have read with attention and interest the manuscript by Fabrizi and colleagues, entitled "The spectrum of Charcot-Marie-Tooth disease due to myelin protein zero: An electrodiagnostic, nerve ultrasound and histological study" (Fabrizi et al., 2018). The authors explored, in a wide way, the characteristics of patients affected by myelin protein zero (MPZ)-related Charcot-Marie-Tooth (CMT) disease. They assessed the patients considering clinical examination, nerve conduction study, ultrasound and, in a patient subgroup, biopsy.

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