The Role of Human Papillomavirus and Epstein-Barr Virus Co-infection in Oropharyngeal Squamous Cell Tumor Differentiation

The recent epidemic of human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC) has resulted in the identification of a patient subpopulation with distinct clinical features and outcomes. Viral-related cancers of the head and neck typically have a better prognosis and response to current standard treatment. As both Epstein-Barr virus (EBV) and HPV are most associated with the lymphoid-rich sites of the head and neck, albeit different sites, we aimed to determine if co-infection of these two viruses plays a role in OPSCC.

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