Abstract
Adverse event
Warfarin related nephropathy
Drug implicated
Warfarin
The patient
A 31 year old female, managed with warfarin for rheumatic heart disease with atrial fibrillation.
Evidence that links the drug to the event
There were no alternative causes of nephropathy that could have caused the adverse event in this patient.
Management
Shifting the drug from warfarin to acenocoumarol
Mechanism, if known
Difference in renal elimination between warfarin and acenocoumarol
Implication for therapy
Clinicians should be aware of this rare adverse effect of warfarin and acenocoumarol can be considered as an alternative therapy for this condition.
Hypotheses to be tested
Further prospectively designed studies are needed to consider acenocoumarol as an alternative therapy in warfarin related nephropathy.
http://ift.tt/2sjHqKB
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.