Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in SBRT for Locally-Recurrent Previously-Irradiated Head and Neck Cancer

In a systematic review of the available literature addressing the dose/volume data for tumor control probability with SBRT in patients with locally-recurrent previously-irradiated head-and-neck cancer, data from over 300 cases in 8 publications suggests that there is a dose-response relationship with superior local control and possibly improved overall survival, for doses of 35-45Gy (in 5 fractions) compared to <30 Gy. SBRT doses equivalent to 5 fraction doses of 40-50Gy are suggested for re-treatment.

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