Insulinoma-associated Protein 1 (INSM1) Differentiates Carcinoid Tumorlets of the Lung from Pulmonary Meningothelial-Like Nodules

Abstract

Insulinoma-associated protein 1 (INSM1) is a zinc-finger transcription factor isolated from pancreatic insulinoma tissue. This protein controls expression of a neuroendocrine phenotype and is responsible for transcription of synaptophysin and chromogranin. In recent years, it has emerged as a sensitive and specific immunohistochemical marker of neuroendocrine neoplasms, and is currently the only commercially available nuclear marker of neuroendocrine differentiation.

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