High-frequency oscillations are not better biomarkers of epileptogenic tissues than spikes

Abstract

Objective: High-frequency oscillations (HFOs) in intracerebral EEG (stereoelectroencephalography, SEEG) are considered as better biomarkers of epileptogenic tissues than spikes. How this can be applied at the patient level remains poorly understood. We investigated how well the HFOs and the spikes can predict epileptogenic regions with a large spatial sampling at the patient level.

Methods: We analyzed non-REM sleep SEEG recordings sampled at 2,048Hz of thirty patients. Ripples (R, 80-250Hz), fast ripples (FR, 250-500Hz) and spikes were automatically detected. Rates of these markers and several combinations – spikes co-occurring with HFOs or FRs and cross rate (Spk⊗HFO) – were compared to a quantified measure of the seizure onset zone (SOZ) by performing a receiver operating characteristic analysis for each patient individually. We used a Wilcoxon sign rank test corrected for false-discovery rate to assess whether a marker was better than the others for predicting the SOZ.

Results: A total of 2930 channels was analyzed (median of 100 channels per patient). The HFOs or any of its variants were not statistically better than spikes. Only one feature, the cross-rate was better than all the other markers. Moreover, fast ripples, even though very specific, were not delineating all epileptogenic tissues.

Interpretation: At the patient level, the performance of the HFOs is weakened by the presence of strong physiological HFO generators. Fast ripples are not sensitive enough to be the unique biomarker of epileptogenicity. Nevertheless, combining HFOs and spikes using our proposed measure –the cross rate– is a better strategy than using only one marker. This article is protected by copyright. All rights reserved.

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