Does Administration of Hypertonic Solutions Improve Mortality in Hemorrhagic Shock Compared With Isotonic Solutions?

Of the 570 identified studies, 12 met inclusion criteria (2,932 patients). Study locations included the United States (8), Brazil (2), the United Kingdom (1), and Australia (1). Settings were out-of-hospital (8), ED (3), and ICU (1). For hypertonic solutions, all 12 studies used 7.5% sodium chloride with or without dextran (4.2% or 6%); 1 study examined hypertonic solutions only, 6 studies examined hypertonic saline with dextran only, and the remaining studies examined both solutions. Control groups used normal saline solution or lactated Ringer's solution.

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