Deciphering extubation failure in extremely preterm infants: Time to embrace complexity and move forward

We read with interest the article by Chawla et al published in The Journal.1 We commend the authors on conducting a subanalysis aiming to improve our understanding of extubation failure from a large sample of extremely preterm infants enrolled in a randomized trial.1 Despite its rigorous design, 3 important points could have enhanced the usefulness of the reported data: (1) use of more complex analyses, (2) extended definition of extubation success, and (3) inclusion of an important confounder when evaluating associations between failure and morbidities.

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