Tumor Necrosis in Radical Prostatectomies with High-Grade Prostate Cancer is Associated with Multiple Poor Prognostic Features and a High Prevalence of Residual Disease

The Gleason Grading System and the recently defined Grade Groups are strong, well-established predictors of outcome in prostate cancer. Each Gleason score, however, is the result of a sum of categories (Gleason Patterns or GP) that are intrinsically heterogeneous, as each individual pattern encompasses several tumor morphologies. While the prognostic value of specific morphologic components of GP4 has recently been demonstrated, the significance of the different patterns of GP5 is largely unknown.

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