The left supramarginal gyrus contributes to finger positioning for object use: A neuronavigated TMS study

Abstract

In everyday actions, we grasp dozens of different manipulable objects in ways that accommodate their functional use. Neuroimaging studies showed that grasping objects in a way that is appropriate for their use involves a left-lateralized network including the supramarginal gyrus (SMG), the anterior intraparietal area (AIP) and the ventral premotor cortex (PMv). However, because previous works premised their conclusions on tasks requiring action execution, it has remained difficult to discriminate between the areas involved in specifying the position of fingers onto the object from those implementing the motor program required to perform the action. To address this issue, we asked healthy participants to make judgements about pictures of manipulable objects while repetitive transcranial magnetic stimulation (rTMS) was applied over the left SMG, AIP, PMv or, as a control, the Vertex. The participants were asked to name the part of the image where the thumb or the index finger was expected to contact the object during its normal utilization or where a given attribute of the same object was located. The two tasks were strictly identical in terms of visual display, working memory demands, and response requirements. Results showed that rTMS over SMG slowed down judgements of finger positions but not judgements of object attributes. Both types of judgements remained unaffected when rTMS was applied over AIP or PMv. This finding demonstrates that, within the parieto-frontal network dedicated to object use, at least the left SMG is involved in specifying the appropriate position of the thumb and index onto the object.

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