High TREM2 expression correlates with poor prognosis in gastric cancer

Triggering receptor expressed on myeloid cells 2 (TREM2) is a member of the immunoglobulin superfamily and associates with TYRO protein tyrosine kinase-binding protein at the cell membrane to form a receptor signaling complex. Gastric cancer (GC) is one of the most common human cancer in the word, we found that TREM2 expression in gastric cancer and adjacent tissues were significantly different. The goal of this study was to measure TREM2 protein and mRNA expression levels in GC tissues and evaluate their value as potential prognostic markers.

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