PARP inhibition combined with thoracic radiation exacerbates esophageal and skin toxicity in C57BL6 mice

PARP inhibitors have been demonstrated to potentiate the anti-tumor effect of radiation in preclinical studies. However, their effect on normal tissue response to radiation is unclear. Here we show that PARP inhibitors not only enhance radiation-induced tumor growth inhibition, but also enhance the response of the esophagus and skin to radiation. Therefore, caution may be warranted when combining PARP inhibition with radiotherapy that includes proliferating normal tissues.

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