Low-dose hypersensitive response for residual pATM and γH2AX foci in normal fibroblasts of cancer patients

We demonstrate, for the first time, low-dose hypersensitive response for both residual pATM and γH2AX foci in normal fibroblasts of 4 HRS-positive patients and its lack in fibroblasts of 8 HRS-negative patients. We also show that in HRS-positive fibroblasts not all DSB are recognized by pATM early after irradiation with low dose. The data provide the evidence for the role of DSB recognition by pATM and repair in the mechanism of HRS.

http://ift.tt/2j6feXt