Follicular large cleaved cell (centrocytic) lymphoma: An unrecognized variant of follicular lymphoma

The World Health Organization (WHO) classification of lymphoma recommends the subdivision of follicular lymphoma (FL) into three grades (FL1–3) based on the average number of centroblasts per high-power field (HPF) in the neoplastic follicles, but does not recognize a form of FL characterized by a predominance of large cleaved cells (centrocytes) without enough centroblasts to meet the WHO criteria for FL3. We have classified such cases as follicular large cleaved cell lymphoma (FLC) and, herein, describe the pathologic and clinical features of 72 cases of this entity.

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