Randomized, Double-blind, Placebo-Controlled Trial of Shuanghuabaihe Tablets to Prevent Oral Mucositis in Patients with Nasopharyngeal Cancer Undergoing Chemoradiotherapy

Shuanghuabaihe tablets have been used for treating recurrent oral mucosa ulceration.Eligible patients (n=240, 18-70 years old) with pathologically diagnosed locally advanced nasopharyngeal carcinoma were randomly assigned (computer-block randomization; 1:1) to receive Shuanghuabaihe tablets or placebo (four tablets, three times a day, for seven weeks) at the initiation of chemoradiotherapy.Shuanghuabaihe tablets reduce the occurrence, latency and severity of oral mucositis in patients with nasopharyngeal cancer during chemoradiotherapy treatment.

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