Prospective phase II trial of permanent seed implantation prostate brachytherapy for intermediate-risk localized prostate cancer: efficacy, toxicity, and quality of life outcomes

We report efficacy, toxicity and quality of life after prostate brachytherapy monotherapy for favorable intermediate risk cancer.Out of 300 patients, after a median follow-up of 5.1 years, only 10 recurrences were reported, yielding a 5-year freedom from biochemical failure rate of 97.3% and a 5-year biochemical progression-free survival rate of 94.9%.Four patients had late grade 3 genitourinary toxicity and two late grade 3 rectal toxicity; no grade 4 or 5 toxicity was observed.

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