Outcomes after re-irradiation for recurrent pediatric intracranial ependymoma

Repeat radiation therapy (RT) for recurrent pediatric ependymoma results in long-term disease control in some patients. Five-year survival was 57% for all patients. Patients with distant-only failure treated with craniospinal irradiation had the best outcomes (5-year survival of 76%). The 10-year incidence of grade 3 or higher radiation necrosis was low at 7.9%. Repeat RT is a feasible, safe, and effective treatment for children with recurrent ependymoma.

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