358 Impact of a Pharmacist-Driven Four-Factor Prothrombin Complex Concentrate Protocol in the Emergency Department at a Large Urban Academic Medical Center

Advancements in the treatment of warfarin-induced intracranial hemorrhage (ICH) include the use of four-factor prothrombin complex concentrate (4F-PCC), which has demonstrated more rapid reversal of the international normalized ratio (INR) when compared with fresh frozen plasma. A pharmacist-driven protocol for 4F-PCC was implemented within our institution which allows for pharmacist approval of 4F-PCC in patients diagnosed with warfarin-induced ICH and an INR ≥2. The pharmacist is responsible for determining the appropriate dose of 4F-PCC, preparing the product, bedside delivery, and entering the order into the electronic medical record.

http://ift.tt/2yNW1fN