The Associative Brain at Work: Evidence from Paired Associative Stimulation Studies in Humans

Donald Hebb's now-famous rule of synaptic plasticity states: "When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased." Although not explicitly stated, the phrase "takes part in firing it" suggests very strongly that there is a close temporal connection between occurrence of the input (A) and the firing of cell B.

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