Subinhibitory Dalbavancin Attenuates Exotoxin Production from Methicillin-sensitive and Methicillin-resistant Staphylococcus aureus in vitro [PublishAheadOfPrint]

This study investigates the effects of subinhibitory doses of the second-generation lipoglycopeptide antibiotic, dalbavancin, on Staphylococcus aureus toxin production in vitro. S. aureus toxin production was compared with the natural glycopeptide antibiotic, vancomycin, and representative beta-lactam and oxazolidinone antibiotics. While neither dalbavancin nor vancomycin adversely increased toxin production, of these glycopeptide antibiotics, only dalbavancin significantly attenuated toxin production as subinhibitory concentrations. These findings support the recent success of dalbavancin for treatment of staphylococcal infections.

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