Silicon Nanoparticles: Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections (Adv. Mater. 35/2017)

In article number 1701527, Sangeeta N. Bhatia and co-workers engineer an antibacterial by fusing two peptide domains to target and kill bacteria and then encapsulate them in a biodegradable porous silicon nanoparticle. These nanomaterials kill bacteria and improve animal survival after treatment of a lung-infection model. This approach represents a new strategy for the development of antibacterials to combat the rising incidence of antibiotic resistance in the clinic.

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