Net1, a therapeutic potential target for cancer

We read with interest the paper by Zhang et al. [1], reporting that Net1 siRNA may reduce the angiogenesis and tumor growth of in vivo cervical squamous cell carcinoma through VEGF down-regulation. The VEGF pathway may represent anti-angiogenic therapy for most cancer types. Ding et al. [2] found that elevated Gab2 could induce tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels. Zhang et al. [1] found that inhibition of Net1 expression resulted in down-regulation of VEGF expression in SiHa cells.

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