Investigating the effect of re-irradiation or systemic therapy in patients with GBM after tumor progression: a secondary analysis of NRG Oncology RTOG 0525

Optimal treatment for glioblastoma patients who progress after standard chemo-radiotherapy remains unknown. We analyzed data from Trial XXXX to investigate the effect of re-irradiation or systemic treatment on survival after progression. Salvage treatment options were found to be highly variable. Patients who received no salvage treatment had significantly shorter survival than those treated after progression. There was no significant survival difference among patients receiving systemic therapy (alone or with radiation) or radiation alone.

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