Ammonium-based methacrylate in an experimental dental adhesive

I read with great interest the article by Nascimento et al in the May 2017 issue on the effects of adding an ammonium-based methacrylate to an experimental dental adhesive for bonding metal brackets.1 I appreciate the authors' goal of preventing white spot lesions by the use of quaternary ammonium monomer. But an issue concerns me. Quaternary ammonium monomers are mainly used as wood preservatives, pesticides, and fungicides, since they exhibit a broad range of antimicrobial activity. The release of free ammonia from quaternary ammonium compounds happens in mixed aerobic cultures.

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