4∗ Serum GFAP and UCH1-L1 Predict Traumatic Injuries on Head CT Scan After Mild-Moderate Traumatic Brain Injury: Results of the ALERT-TBI Multicenter Study

There exists a critical unmet medical need to improve the assessment and management of traumatic brain injury (TBI), a leading cause of injury, death and disability in the United States. Despite growing recognition and research of the importance and potential of biomarkers for TBI, there are currently no FDA-cleared or approved objective blood tests for TBI or concussion. Ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) are two novel biomarker candidates that are highly brain specific and are detectable in the serum shortly after TBI.

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