Results of a 36-year surveillance program for ulcerative colitis-associated neoplasia in the Japanese population

Abstract

Background

Surveillance colonoscopy has been performed for patients with long-standing ulcerative colitis, who have an increased risk for colorectal cancer. The aim of this study was to determine the incidence of and the risk factors for neoplasia.

Methods

We evaluated 289 ulcerative colitis patients who underwent surveillance colonoscopy between January1979 and December 2014. The cumulative incidence of neoplasia and its risk factors were investigated. The clinical stage and overall survival were compared between the surveillance and non-surveillance groups.

Results

The cumulative risk of dysplasia was 3.3%, 12.1%, 21.8%, and 29.1% at 10, 20, 30 and 40 years after the onset of ulcerative colitis, respectively. The cumulative risk of colorectal cancer was 0.7%, 3.2%, 5.2%, and 5.2% at 10, 20, 30 and 40 years from the onset of ulcerative colitis, respectively. Total colitis was a risk factor for neoplasia (p=0.015; hazard ratio, 2.96).

Conclusions

Our surveillance colonoscopy program revealed the incidence and risk factors of ulcerative colitis-associated neoplasias in Japanese population. Total colitis was a risk factor for neoplasia.

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