P219 Cortical excitability in Dystrophia Myotonica type 1

Dystrophia Myotonica type 1 (DM1) is characterized by distal muscle weakness, atrophy, myotonia and CNS involvement. Electrophysiological assessment of CNS involvement in DM1 patient refers to multimodal evoked potential studies. Herein we investigated the function of central motor pathways in DM1 patients by transcranial magnetic stimulation (TMS) and the possible relationships with disease duration, muscular impairment and MRI findings.

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