Oolong tea polyphenols-phospholipids complex reduces obesity in high fat diet-induced mice model

Abstract

In this study, the anti-obesity effect of oolong tea polyphenols-phospholipids complex (OTC) was investigated. OTC was prepared with oolong tea polyphenols (OTP) and phospholipids, and exhibited higher stability than OTP in vitro. Then high fat diet-induced obesity human flora-associated (HFA) mice model were obtained, and the administration of both OTP and OTC alleviated the changes of the serum and liver levels induced by high fat diet dramatically. The numbers (log₁₀ cell/mL) of Bifidobacterium and Lactobacillus/Enterococcus spp., Bacteroides-Prevotella and Clostridium histolyticum in obesity models fed with OTC after 8 weeks were 8.28 ± 0.03, 8.21 ± 0.01, 7.23 ± 0.02, and 7.05 ± 0.03 compared with 8.21 ± 0.02, 8.07 ± 0.02, 7.31 ± 0.02, and 7.10 ± 0.01, respectively, in the control. Together, it confirmed the potential of phospholipids in the promotion of intestinal transport of polyphenols, suggesting OTC may have prebiotic-like activity to prevent obesity-related metabolic disorders.

Practical applications: For good bioavailability, tea polyphenols should have a balance between hydrophilicity and lipophilicity. The preparation of oolong tea polyphenols-phospholipids complex may effectively improve the overall absorption of oolong tea polyphenols. This study could provide information about the potential of phospholipids in the promotion of bioavailability and obesity prevention effect of oolong tea polyphenols, and our investigation may be fascinated in manufacturing functional foods that support improved tea polyphenols absorption.

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