Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

It is unclear how DNA sensing by DCs is superior to macrophages. Xu et al. show that DCs are specialized in sensing mtDNA after CD47 blockade through inhibiting uptaken DNA degradation in their phagosomes while macrophages rapidly degrade DNA.

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