Our back cover shows immunohistochemical staining of active STAT3 in a tumor in the colon of Card9-deficient mice following chronic AOM/DSS treatment. The image is taken from Bergmann and Roth et al. (pp. 1342–1353), where the authors show that Card9-deficient mice have an impaired production of the innate cytokine IL-1β during colitis in the colon and a subsequent reduced production of IL-22 from innate lymphoid cells during epithelial repair and tumor growth. STAT3 is the major transcription factor activated by immune cell derived IL-22 on intestinal epithelial cells and Card9-deficient mice display a reduced activation within regenerating epithelial cells and tumors.
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