Our front cover features representative sections of immunohistochemical staining of IDO distribution in the kidney from NZB/NZW F1 female mice treated with pegylated-anti-CD28 Fab' fragment. The image is taken from Laurent et al. (pp. 1368–1376), where the authors show that CD28 blockade increases IDO expression in renal tissue. IDO expression is more marked in the anti-CD28 Fab'-treated group compared to controls, mainly in the upper layer of the cortex and in the tubular regions.
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