Vacancy-Driven Gelation Using Defect-Rich Nanoassemblies of 2D Transition Metal Dichalcogenides and Polymeric Binder for Biomedical Applications

A new approach of vacancy-driven gelation to obtain chemically crosslinked hydrogels from defect-rich 2D molybdenum disulfide (MoS₂) nanoassemblies and polymeric binder is reported. This approach utilizes the planar and edge atomic defects available on the surface of the 2D MoS₂ nanoassemblies to form mechanically resilient and elastomeric nanocomposite hydrogels. The atomic defects present on the lattice plane of 2D MoS₂ nanoassemblies are due to atomic vacancies and can act as an active center for vacancy-driven gelation with a thiol-activated terminal such as four-arm poly(ethylene glycol)–thiol (PEG-SH) via chemisorption. By modulating the number of vacancies on the 2D MoS₂ nanoassemblies, the physical and chemical properties of the hydrogel network can be controlled. This vacancy-driven gelation process does not require external stimuli such as UV exposure, chemical initiator, or thermal agitation for crosslinking and thus provides a nontoxic and facile approach to encapsulate cells and proteins. 2D MoS₂ nanoassemblies are cytocompatible, and encapsulated cells in the nanocomposite hydrogels show high viability. Overall, the nanoengineered hydrogel obtained from vacancy-driven gelation is mechanically resilient and can be used for a range of biomedical applications including tissue engineering, regenerative medicine, and cell and therapeutic delivery.

A new approach of vacancy-driven gelation to obtain chemically crosslinked hydrogels from defect-rich nanoassemblies of 2D transition metal dichalcogenides and polymeric binder is presented. The approach utilizes planar and edge atomic defects available on the surface of 2D MoS₂ to form a chemically reinforced mechanically resilient nanocomposite network. Mechanically stiff and elastomeric nanocomposites hydrogels can be used to encapsulate cells for biomedical applications.

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