Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact [PublishAheadOfPrint]

Linezolid serum trough (Cmin) and peak levels were determined prospectively in 90 patients. Adequate exposure was defined as a Cmin of 2-8 mg/L. Therapy was empirical (73.3%) or targeted (26.7%). Wide interindividual variability in linezolid trough levels was recorded (0.1-25.2 μg/mL). Overall 65.5% of the patients had out of range trough levels, 41.1% subtherapeutic and 24.4% supratherapeutic.

We did not find a correlation between abnormal levels and adverse events, in-hospital mortality, or overall poor outcome.

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