Synaptic damage underlies EEG abnormalities in postanoxic encephalopathy: a computational study

Of all comatose survivors of cardiac arrest, 46-48% are alive and independent in activities of daily living after 6 months (Hofmeijer et al., 2015; Nielsen et al., 2013). Continuous electroencephalography (cEEG) in the first 24 hours after resuscitation allows reliable identification of 50% of patients with either a good or poor outcome (Hofmeijer et al., 2015). Not only the EEG abnormalities as such, but also their timing and evolution are crucial indicators of the severity of the ischemic injury and prognosis (Tjepkema-Cloostermans et al., 2015).

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