High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus

The localization of the "epileptogenic zone" is a crucial factor in epilepsy surgery for patients with medically refractory partial epilepsy. While several non-invasive examinations, such as scalp electroencephalogram (EEG), magnetoencephalography, magnetic resonance imaging (MRI), F-18-fluorodeoxyglucose - Positron Emission Tomography (FDG-PET), and ictal single-photon emission computed tomography (SPECT), are useful to evaluate the epileptogenic zone, these results are occasionally insufficient (Lesser et al., 2010), requiring an additional intracranial EEG evaluation.

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