Objectives: To characterize the temporal pattern of a panel of blood and urinary biomarkers in an animal model of fecal peritonitis and recovery. Design: Prospective observational animal study. Setting: University research laboratory. Subjects: Male Wistar rats. Interventions: A fluid-resuscitated, long-term (3 d) rat model of sepsis (fecal peritonitis) and recovery was used to understand the temporal association of sepsis biomarkers in relation to systemic hemodynamics, inflammation, and renal function. At predefined time points (3, 6, 12, 24, 48, 72 hr), animals (>= 6 per group) underwent echocardiography, blood and urine sampling, and had kidneys taken for histological analysis. Comparison was made against sham-operated controls and naive animals. Measurements and Main Results: The systemic proinflammatory response was maximal at 6 hours, corresponding with the nadir of stroke volume. Serum creatinine peaked late (24 hr), when clinical recovery was imminent. Histological evidence of tubular injury and cell death was minimal. After a recovery period, all biomarkers returned to levels approaching those observed in sham animals. Apart from urine clusterin and interleukin-18, all other urinary biomarkers were elevated at earlier time points compared with serum creatinine. Urine neutrophil gelatinase-associated lipocalin was the most sensitive marker among those studied, rising from 3 hours. While serum creatinine fell at 12 hours, serum cystatin C increased, suggestive of decreased creatinine production. Conclusions: Novel information is reported on the temporal profile of a panel of renal biomarkers in sepsis in the context of systemic and renal inflammation and recovery. Insight into the pathophysiology of acute kidney injury is gleaned from the temporal change markers of renal injury (urine neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, calbindin), followed by a marker of cell cycle arrest (urine insulin-like growth factor-binding protein 7) and, finally, by functional markers of filtration (serum creatinine and cystatin C). These clinically relevant findings should have significant influence on future clinical testing. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright (C) by 2017 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
http://ift.tt/2syfQUP
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
▼
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
Ιουλίου
(5714)
-
▼
Ιουλ 01
(93)
- Utility of somatosensory evoked potentials in the ...
- Treatment of Gabapentin Toxicity With Peritoneal D...
- Erratum Regarding “Phosphate-Binding Agents in Adu...
- Association between F508 deletion in CFTR and chro...
- The terminal latency of the phrenic nerve correlat...
- SCOPE-mTL: a non-invasive tool for identifying and...
- Effects of Bu Shen Yi sui capsule on NogoA/NgR and...
- Hospitalization Rates during Potentially Inappropr...
- Co-morbidity and polypharmacy in Parkinson’s disea...
- Extraction of Organochlorine Pesticides from Plast...
- Distribution of Vascular Patterns in Different Sub...
- Identification of Potential Gene Network Associate...
- Greater diversity of soil fungal communities and d...
- Sequence of inoculation influences the nature of e...
- Pooled Analysis of Clinical Outcome of Patients wi...
- Magnesium-Zinc-Calcium-Vitamin D Co-supplementatio...
- Lower Cranial Nerves Paralysis Following Prone-Pos...
- Hydrogen Sulfide Confers Lung Protection During Me...
- Efficacy and Safety of Combination Therapy of Shen...
- Preadmission Use of Calcium Channel Blocking Agent...
- The Impact of Mortality on Total Costs Within the ...
- Faster Blood Flow Rate Does Not Improve Circuit Li...
- Both Positive and Negative Fluid Balance May Be As...
- Determinants of Receiving Palliative Care and Vent...
- Organ Support After Death by Neurologic Criteria i...
- Validation of an Administrative Definition of ICU ...
- Transcranial Doppler Microemboli Monitoring for St...
- Sequential Analysis of a Panel of Biomarkers and P...
- Neurobiologic Correlates of Attention and Memory D...
- Brain Gray Matter MRI Morphometry for Neuroprognos...
- Identifying Distinct Subgroups of ICU Patients: A ...
- Brain-Dead Donors on Extracorporeal Membrane Oxyge...
- Challenging Authority During an Emergency-the Effe...
- Preventing Harm in the ICU-Building a Culture of S...
- Repeated Critical Illness and Unplanned Readmissio...
- Molecular Adsorbent Recirculating System Can Reduc...
- Current challenges in the management of follicular...
- Survivors at risk: Hodgkin lymphoma survivors at h...
- Updated classification and novel treatment prospec...
- The bone marrow transplant clinical nurse speciali...
- Clinically node negative breast cancer patients un...
- Inhibition of HDAC6 activity through interaction w...
- Persistent accumulation of gut macrophages with im...
- Flt3 ligand-eGFP-reporter expression characterizes...
- Associations between treatment, scoliosis, pulmona...
- Synthesis and evaluation of novel thiazole-based d...
- Preparation, characterization and in vitro evaluat...
- Influence of EGCG on α-synuclein (αS) aggregation ...
- Production of Chemicals from Microalgae Lipids – S...
- Lactobacilli survival and adhesion to colonic epit...
- The effects of 2-hydroxyethyl methacrylate on matr...
- MTA-induced Notch activation enhances the prolifer...
- Micro-CT assessment of the shaping ability of four...
- The five-year cost-effectiveness of two-level ante...
- Lumbar spine surgery in patients with rheumatoid a...
- Risk factors for laryngeal penetration-aspiration ...
- Motion preservation following total lumbar disc re...
- The impact of spine stability on cervical spinal c...
- Gender trends in authorship of spine-related acade...
- Incorporating ligament laxity in a finite element ...
- The medico-legal landscape of spine surgery: how d...
- When cancer patients suddenly have a positive preg...
- Faecaloma causing large bowel obstruction: a case ...
- Is cystic artery lymph node excision during laparo...
- miRNome landscape analysis reveals a 30 miRNA core...
- Phase I study of salazosulfapyridine in combinatio...
- Accelerated growth of B16BL6 tumor in mice through...
- ETB receptor contribution to vascular dysfunction ...
- Histone deacetylase activity modulates exercise-in...
- Intermittent hypoxia training blunts cerebrocortic...
- Sex-specific effects of stress on metabolic and ca...
- Use of the hyperinsulinemic euglycemic clamp to as...
- Impact of acetaminophen consumption and resistance...
- Role of endothelial nitric oxide in control of per...
- Autophagy upregulates (pro)renin receptor expressi...
- Validation of a DICE Simulation Against a Discrete...
- Consolidation hyperthermic intraperitoneal chemoth...
- Cancers, Vol. 9, Pages 75: Pleiotropic Roles of No...
- Increased migration of antigen presenting cells to...
- Immunosenescence: the Role of Aging in the Predisp...
- Monitoring the Brain After Cardiac Arrest: a New Era
- A preoperative score to predict early death after ...
- Kinase Inhibitors in the Treatment of Myeloid Mali...
- Contents
- Mechanisms of Resistance to ABL Kinase Inhibition ...
- Tyrosine Kinase Inhibitors in the Treatment of Eos...
- The Treatment of Myeloid Malignancies with Kinase ...
- Copyright
- Contributors
- Tyrosine Kinase Inhibitor Treatment for Newly Diag...
- Forthcoming Issues
- Fatal Dialysis Vascular Access Hemorrhage
- Cancers, Vol. 9, Pages 74: Specific Depletion of L...
-
▼
Ιουλ 01
(93)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.