Effect of Brain Tumor Presence During Radiation on Tissue Toxicity: Transcriptomic and Metabolic Changes

An allograft brain tumor model was irradiated to isolate the effect of the tumor on damage to surrounding tissue post-irradiation. Comparison of Radiation+tumor implant versus Radiation+sham implant groups allowed isolation of the tumor effect on long-term radiation-induced damage. Our data indicate that tumor presence during radiation significantly affects late-term functional transcriptomic and neurotransmitter levels at the tumor implantation site/normal tissue, accompanied by functional changes in astrogliosis.

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